Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation.
Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV16/18 E6 expression correlated inversely with p53 expression, which was further...
متن کاملProduction of Human Papilloma Virus Type 16 E6 Oncoprotein as a Recombinant Protein in Eukaryotic Cells
BACKGROUND Cervical cancer is one of the most important and widespread cancer which affects women. There are several causes of cervical cancer; among them HPV types 16 and 18 are the most prominent ones which are recurrent and persistent infections. These genotypes are currently about 70% of cervical cancer causes in developing countries. Due to the importance of these viruses in cervical cance...
متن کاملE6-associated transcription patterns in human papilloma virus 16-positive cervical tissues
The change in transcription pattern induced by post-transcriptional RNA splicing is an important mechanism in the regulation of the early gene expression of human papilloma virus (HPV). The present study was conducted to establish a method to specifically amplify HPV-16 E6-associated transcripts. The E6-related transcripts from 63 HPV-16-positive cervical tumor tissue samples were amplified, co...
متن کاملAssociation of Human Papilloma Virus and Epstein-Barr Virus with Ovarian Cancer in Shiraz, Southwestern Iran
Background & Objective: Ovarian cancer is one of the most common cancers amongst women. The association of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) with ovarian cancer is inconclusive; therefore, the aims of this study were to evaluate the frequency of HPV and EBV in malignant, ...
متن کاملHuman papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation.
PURPOSE Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) carries a distinct clinical behaviour. c-Met oncogene is an important driver for tumour progression and its relationship with HPV in OPSCC was explored in the present study. EXPERIMENTAL DESIGN Knockdown of HPV oncogene E6 or p53 alone and in combination was performed to examine their effects on c-Met ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2012
ISSN: 1007-9327
DOI: 10.3748/wjg.v18.i30.4051